Calcim Uniporter - Previous Model
From BioComputationWiKi
Contents |
Model Authors
Ranjan K. Dash and Daniel A. Beard
Biotechnology and Bioengineering Center, Department of Physiology
Medical College of Wisconsin
dbeard@mcw.edu
This model is described in detail in the following publication:
Dash, RK and Beard, DA. Analysis of Cardiac Mitochondrial Na+/Ca2+ Exchanger Kinetics with a Biophysical Model of Mitochondrial Ca2+ Handing Suggests a 3:1 Stoichiometry. J Physiol, 2008.
[Read on PubMed]
Function
Ca++ is taken up in energized mitochondria via the Calcium Uniporter (CU). It is driven by the electrochemical gradient of Ca++ across the inner mitochondrial membrane (IMM). It also depends on the kinetics of Ca++ binding to the CU.
The mechanism for doing this is illustrated in the following schematic:
Data Used To Parameterize the Model
All data was taken from the following sources:
- Scarpa A & Graziotti P. (1973). Mechanisms for intracellular calcium regulation in heart. I. Stopped-flow measurements of Ca2+ uptake by cardiac mitochondria. J Gen Physiol 62, 756-772. [Read on PubMed]
- Vinogradov A & Scarpa A. (1973). The initial velocities of calcium uptake by rat liver mitochondria. J Biol Chem 248, 5527-5531 [Read on PubMed]
- Wingrove DE, Amatruda JM & Gunter TE. (1984). Glucagon effects on the membrane potential and calcium uptake rate of rat liver mitochondria. J Biol Chem 259, 9390-9394. [Read on PubMed]
- Gunter TE & Pfeiffer DR. (1990). Mechanisms by which mitochondria transport calcium. Am J Physiol 258, C755-786. [Read on PubMed]
- Gunter TE, Gunter KK, Sheu SS & Gavin CE. (1994). Mitochondrial calcium transport: physiological and pathological relevance. Am J Physiol 267, C313-339. [Read on PubMed]
Model Specification Sheet
Calcium Uniporter (Previous Model) Specification Sheet
Back to Transporters
Back to Biological Components Databank
