Calcium Uniporter - 2
From BioComputationWiKi
Contents |
Model Authors
Ranjan K. Dash, Feng Qi and Daniel A. Beard
Biotechnology and Bioengineering Center, Department of Physiology
Medical College of Wisconsin
dbeard@mcw.edu
This model is described in detail in the following publication:
Dash, RK, Qi, Feng and Beard, DA. A Biophysically-Based Mathematical Model for the Kinetics of Mitochondrial Calcium Uniporter. (Manuscript in Review), 2008.
Function
Ca++ is taken up in energized mitochondria via the Calcium Uniporter (CU). It is driven by the electrochemical gradient of Ca++ across the inner mitochondrial membrane (IMM). It also depends on the kinetics of Ca++ binding to the CU.
The mechanism for doing this is illustrated in the following schematic:
Data Used To Parameterize the Model
All data was taken from the following sources:
- Vinogradov, A., and A. Scarpa. 1973. The initial velocities of calcium uptake by rat liver mitochondria. J Biol Chem 248(15):5527-5531.[Read on PubMed]
- Gunter, T.E., and D.R. Pfeiffer. 1990. Mechanisms by which mitochondria transport calcium. Am J Physiol 258(5 Pt 1):C755-786.[Read on PubMed]
- Wingrove, D.E., J.M. Amatruda, and T.E. Gunter. 1984. Glucagon effects on the membrane potential and calcium uptake rate of rat liver mitochondria. J Biol Chem 259(15):9390-9394.[Read on PubMed]
- Scarpa, A., and P. Graziotti. 1973. Mechanisms for intracellular calcium regulation in heart. I. Stopped-flow measurements of Ca2+ uptake by cardiac mitochondria. J Gen Physiol 62(6):756-772.[Read on PubMed]
- Kirichok, Y., G. Krapivinsky, and D.E. Clapham. 2004. The mitochondrial calcium uniporter is a highly selective ion channel. Nature 427(6972):360-364.[Read on PubMed]
Model Specification Sheet
Calcium Uniporter - 2 Specification Sheet
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