Citrate Synthase

From BioComputationWiKi

Contents 1 Model Authors 2 Reaction Definition 3 Data Used to Parameterize the Model 4 Model Specification Sheet 5 CellML - Citrate Synthase Model

Model Authors

Daniel A. Beard, Kalyan Vinnakota, Fan Wu Biotechnology and Bioengineering Center and Department of Physiology Medical College of Wisconsin dbeard@mcw.edu This model is described in detail in the following publication: [Read Paper Here] MathML Back to Enzymes Back to Biological Components Databank

Citrate Synthase Specification Sheet

Reaction Definition

Citrate synthase is the first step in the oxidation of acetyl-CoA in the citric acid cycle. The reference chemical reaction is

The biochemical reaction, involving biochemical reactants that are sums of species, is

The reaction diagram is

Data Used to Parameterize the Model

All data was taken from the following sources:

1. Alberty, R. A. (2003) Thermodynamics of Biochemical Reactions, John Wiley & Sons, Hoboken, N.J.
2. Matsuoka, Y., and Srere, P. A. (1973) J Biol Chem 248(23), 8022-8030 [Read Paper on PubMed]
3. Shepherd, D., and Garland, P. B. (1969) Biochem J 114(3), 597-610 [Read Paper on PubMed]
4. Smith, C. M., and Williamson, J. R. (1971) FEBS Lett 18(1), 35-38

Model Specification Sheet

Document contains model details, including data fits and parameter estimates.

All concentrations used in the flux equations presented in this sheet are free ion concentraions. To derive the free ion concentration from the total concentration, Click Here

Citrate Synthase Specification Sheet

CellML - Citrate Synthase Model

Citrate Synthase CellML model

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