Sodium-Calcium Exchanger
From BioComputationWiKi
Contents |
Model Authors
Ranjan K. Dash and Daniel A. Beard
Biotechnology and Bioengineering Center, Department of Physiology
Medical College of Wisconsin
dbeard@mcw.edu
This model is described in detail in the following publication:
Dash, RK and Beard, DA. Analysis of Cardiac Mitochondrial Na+/Ca2+ Exchanger Kinetics with a Biophysical Model of Mitochondrial Ca2+ Handing Suggests a 3:1 Stoichiometry. J Physiol, 2008.
[Read on PubMed]
Function
Ca++ is primarily extruded from respiring and non-respiring mitochondria in exchange for Na+ via the NCE. Although still up for debate, the model described here shows that the stoichiometric ratio of Na+ to Ca++ is 3:1.
Data Used to Parameterize the Model
All data was taken from the following sources:
- Paucek P & Jaburek M. (2004). Kinetics and ion specificity of Na+/Ca2+ exchange mediated by the reconstituted beef heart mitochondrial Na+/Ca2+ antiporter. Biochim Biophys Acta 1659, 83-91. [Read on PubMed]
- Cox DA & Matlib MA. (1993). A role for the mitochondrial Na+-Ca2+ exchanger in the regulation of oxidative phosphorylation in isolated heart mitochondria. J Biol Chem 268, 938-947. [Read on PubMed]
Model Specification Sheet
Sodium-Calcium Exchanger Specification Sheet
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