Sodium-Hydrogen Exchanger
From BioComputationWiKi
Contents |
Model Authors
Ranjan K. Dash and Daniel A. Beard
Biotechnology and Bioengineering Center, Department of Physiology
Medical College of Wisconsin
dbeard@mcw.edu
This model is described in detail in the following publication:
Dash, RK and Beard, DA. Analysis of Cardiac Mitochondrial Na+/Ca2+ Exchanger Kinetics with a Biophysical Model of Mitochondrial Ca2+ Handing Suggests a 3:1 Stoichiometry. J Physiol, 2008.
[Read on PubMed]
Function
The Na+, which enters the matrix in exchange of Ca2+ via the NCE, is extruded from the matrix in exchange of H+ via the NHE. The function of the NHE is to maintain a low [Na+] (2–5 mM) in respiring mitochondria to favor the influx of Na+ and efflux of Ca2+ via the NCE. So the mitochondrial NHE plays a role in regulating mitochondrial Na+-Ca2+ cycle, and hence mitochondrial Ca2+ dynamics.
Data Used to Parameterize the Model
All data was taken from the following sources:
- Kapus A, Ligeti E & Fonyo A. (1989). Na+/H+ exchange in mitochondria as monitored by BCECF fluorescence. FEBS Lett 251, 49-52. [Read on PubMed]
- Kapus A, Lukacs GL, Cragoe EJ, Jr., Ligeti E & Fonyo A. (1988). Characterization of the mitochondrial Na+-H+ exchange. The effect of amiloride analogues. Biochim Biophys Acta 944, 383-390. [Read on PubMed]
Model Specification Sheet
Sodium-Hydrogen Exchanger Specification Sheet
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