Calcium Uniporter - Updated Model

From BioComputationWiKi

Model Authors

Ranjan K. Dash and Daniel A. Beard
Biotechnology and Bioengineering Center, Department of Physiology
Medical College of Wisconsin
dbeard@mcw.edu

This model is described in detail in the following publication:
Dash, RK and Beard, DA. A Biophysically-Based Mathematical Model for the Kinetics of Mitochondrial Calcium Uniporter. (Manuscript in Review), 2008.

Function

Ca++ is taken up in energized mitochondria via the Calcium Uniporter (CU). It is driven by the electrochemical gradient of Ca++ across the inner mitochondrial membrane (IMM). It also depends on the kinetics of Ca++ binding to the CU.

The mechanism for doing this is illustrated in the following schematic:

Data Used To Parameterize the Model

All data was taken from the following sources:

Model Specification Sheet

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