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==Model Authors== <table width="1200" height="163" border="0"> <tr> <td width="600" height="159" align="left" valign="top"> Daniel A. Beard, Kalyan Vinnakota, Fan Wu<br /> Biotechnology and Bioengineering Center and Department of Physiology<br /> Medical College of Wisconsin<br /> [mailto:dbeard@mcw.edu dbeard@mcw.edu]<br /> This model is described in detail in the following publication: [[http://www.plosone.org/article/info:doi%2F10.1371%2Fjournal.pone.0001825 Read Paper Here]] <br> [http://june.phys.mcw.edu/BioWiki/images/a/ae/CitrateSynthase.xml MathML] <br /> <br /> <br /> Back to [[Enzymes]]<br /> Back to [[Biological Components Databank]] </td> <td width="318" align="right" valign="top"> <linkedimage> wikipage=images/8/8d/Citrate_Synthase_Specification_Sheet.pdf tooltip=Citrate Synthase Specification Sheet img_src=Image:Citrate_Synthase5.png‎ img_width=100% img_height=100% </linkedimage> <br /> [[Media:Citrate_Synthase_Specification_Sheet.pdf|Citrate Synthase Specification Sheet]] </td> </tr> </table> ==Reaction Definition== Citrate synthase is the first step in the oxidation of acetyl-CoA in the citric acid cycle. The reference chemical reaction is<br /> <br /> [[Image:CitrateSynthaseEq3.png|center]] The biochemical reaction, involving biochemical reactants that are sums of species, is<br /> <br /> [[Image:CitrateSynthaseEq4.png|center]] The reaction diagram is<br /> <br /> [[Image:CTSMechanism.png|center]] ==Data Used to Parameterize the Model== All data was taken from the following sources:<br /> #Alberty, R. A. (2003) Thermodynamics of Biochemical Reactions, John Wiley & Sons, Hoboken, N.J. #Matsuoka, Y., and Srere, P. A. (1973) J Biol Chem 248(23), 8022-8030 [[http://www.ncbi.nlm.nih.gov/pubmed/4201777?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum Read Paper on PubMed]] #Shepherd, D., and Garland, P. B. (1969) Biochem J 114(3), 597-610 [[http://www.ncbi.nlm.nih.gov/pubmed/5820645?ordinalpos=5&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum Read Paper on PubMed]] #Smith, C. M., and Williamson, J. R. (1971) FEBS Lett 18(1), 35-38 ==Model Specification Sheet== Document contains model details, including data fits and parameter estimates.<br /> <br /> All concentrations used in the flux equations presented in this sheet are free ion concentraions. To derive the free ion concentration from the total concentration, [[Some webpage|Click Here]] [[Media:Citrate_Synthase_Specification_Sheet.pdf|Citrate Synthase Specification Sheet]] == CellML - Citrate Synthase Model == [[Citrate Synthase CellML model]] <br /> Back to [[Enzymes]]<br /> Back to [[Biological Components Databank]]

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